YPInterimTesting: Interim Monitoring Using Adaptively Weighted Log-Rank Test in
Clinical Trials
For any spending function specified by the user, this
package provides corresponding boundaries for interim testing using
the adaptively weighted log-rank test developed by Yang and Prentice
(2010 <doi:10.1111/j.1541-0420.2009.01243.x>).
The package uses a re-sampling method to obtain stopping boundaries
at the interim looks.The output consists of stopping boundaries
and observed values of the test statistics at the interim looks,
along with nominal p-values defined as the probability of the test
exceeding the specific observed test statistic value or critical
value, regardless of the test behavior at other looks.
The asymptotic validity of the stopping boundaries is established
in Yang (2018 <doi:10.1002/sim.7958>).
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